School of Pharmaceutical
Sciences of Ribeirão Preto

University of São Paulo



Department of Clinical Analyses, Toxicology and Food Science

The Department of Clinical Analyses, Toxicology and Food Science consists of 37 faculty members, of which 8 Full Professors, 10 Associate Professors and 19 Doctor Professors. The current structure of the Department in terms of non-teaching employees is 11 Superior Education Level Laboratory Experts, 27 High School Level Laboratory Technicians, 9 Fundamental Level Laboratory Auxiliaries, 1 Administrative Technician and 5 secretaries.

Department of Clinical Analyses, Toxicology and Food Science mission is to develop teaching, research and university extension in an articulated manner in the areas of Basic and Applied Biosciences to Pharmacy, Food Science and Toxicology aiming at training human resources to become highly qualified with a humanistic and reflexive view committed with scientific development in the border of knowledge, and with the mission of transferring knowledge based on social reality, cultural development, and on improvement of the quality of life of society.

The Department Board is in charge of the academic-administrative management. It discuss how to plan the activities schedule based on academic goals plan, data collection and suggestions for improvement given to establish policies, develop strategies and concentrate resources. It is important to highlight that the Department has the following Committees: Research, Undergraduate and Graduate Studies; Internship in Clinical Analysis, Toxicology and Food Science; Physical Space and Budget. The Department has been investing in the training of research networks, in carrying out integrated actions with faculty members from other Departments and Units, in sharing equipment infrastructure and human resources, in prioritizing multidisciplinary teaching laboratories, in reducing rework, in computer use for communication, optimizing the duration of meetings, in agility of decision-making processes, and in encouraging research meetings to be held via video conference.

Department faculty members develop their research activities in 2 main areas, distributed in Biosciences Applied to Pharmacy (76%) and Toxicology (24%). The main research lines in Biosciences Applied to Pharmacy may be divided into: 1-Understanding of the relation parasite-host and the pathophysiology of human diseases such as infectious, inflammatory, lymphoproliferative or degenerative. 2-Search for molecular markers and virulence factors of pathogens aiming to discover new therapeutic targets, development of vaccines and more accurate and innovative techniques for diagnosis. 3-Use of microorganisms as bioremediation or cell biology studies instrument. 4-Evaluation of public health policies. Regarding Toxicology area, the main research lines are: 1-Toxinology:  Animals venomous and anti-venomous of plant origin - characterization and mechanisms of action. 2- Toxicodynamics: Neurotoxicants, mitochondrial dysfunction, excitotoxicity and cell redox state in neurodegenerative diseases and neurotoxicity, neuroprotection strategies. 3-Environmental Toxicology: Studies on biomonitoring, and spectrometric and spectroscopic techniques development applied to the analysis of chemical elements and emerging contaminants; Assessment of genotoxic and mutagenic activity in compounds of environmental interest; Assessment of antigenotoxic and antimutagenic activities of dietary components; Modulation of bioactive dietary compounds on gene expression and gene methylation processes; Drug-food interaction. 4- Clinical Toxicology: Clinical studies of the adverse effects of drugs; Influence of diseases and drug-drug interaction in the pharmacokinetics and PK-PD modelling of drugs, in particular chiral drugs. Therefore, we may say the Department faculty members research lines, although they are comprehensive, they converge to a common focus, which is the Human Health, in the wide Pharmaceutical area.

Department Faculty members have participated as Main or Responsible Researchers in 6 FAPESP Thematic Projects: 1-Animal Toxins: biotechnological structure, functions and applications; 2-Native and Recombinant Animal Toxins: functional, structural and molecular analysis; 3- Lipid Measures as regulators of immune response; 4-New Functional Aspects of eicosanoids; 5-Food Safety Improvement for elimination of mixed-species biofilm pathogens; 6-Integrated Assessment of the Stability and Functional Properties of Natural Food Colorings. Department Faculty members have also participated as Coordinators or Associate Researchers in: a) 3 Research Support Centers: NAP-TOXAN-Animal Toxins; NAPAN-Food And Nutrition and NPPNS-Natural and Synthetic Products); b) 3 Brazilian National Institute of Science and Technology: INCT-IF- Pharmaceutical Innovation; INCTC-Cytotherapy, and INAIRA- Environmental Risk Integrated Analysis; c) 1 FINEP CT-INFRA Agreement; and d) 2 Research, Innovation and Dissemination Centers: CEPID-Food Research Center and CEPID-Cytotherapy Center. Research facilities, under the responsibility of the Department faculty members, are represented by the Flow Cytometry Laboratory, and by Nucleic Acids Sequencing Center.

In graduate programs, Department participation is found mainly in the Biosciences Applied to Pharmacy Graduate Program and Toxicology Graduate Program. It is important to highlight that Department faculty members are also advisors in the Medical School Gradute Programs: Basic and Applied Immunology; Biochemistry; Hemotherapy and Molecular and Cell Biology. Department connections and cooperation with national and international similar research institutes are strong and growing.

Undergraduate students engagement in research activities is highly evident in Scientific Initiation Program and in the Introduction to Science Program (PRÓ-CIÊNCIA). Department faculty members have also participated in the Pre-Scientific Initiation Program, which aims to support research projects that may encourage and stimulate interest in public school students.

Connections and cooperation between graduate and undergraduate teaching in the Education Improvement Program (PAE) are solid and meant to improve graduate students training for undergraduate teaching activities upon graduate student participation in undergraduate disciplines.