Mônica T. Pupo, Laboratory of Microbial Chemistry (LQMo)
University of Sao Paulo, School of Pharmaceutical Sciences of Ribeirão Preto, Department of Pharmaceutical Sciences.
Avenida do Café s/n Monte Alegre
CEP: 14040-903 – Ribeirao Preto, SP – Brasil
Phone number: + 55 16 36024710
Curriculum Vitae (CV): http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4784661H0
Mônica T. Pupo got her PhD in Sciences, Organic Chemistry area (1997) at the Department of Chemistry of Federal University of São Carlos, under Prof. Paulo C. Vieira supervision. She was a post-doctoral fellow at the Physics Institute of São Carlos,UniversityofSão Paulo, under Prof. Glaucius Oliva supervivion (1997-1998), and at the Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,USA, under Jon Clardy supervision (2006-2007).
She is an associate professor at the Department of Pharmaceutical Sciences since 2009, where she was assistant professor during 1998-2009. She teaches Pharmaceutical Chemistry I and Pharmaceutical Chemistry II for Pharmacy undergraduates, and Structural Elucidation of Organic Compounds for Pharmaceutical Sciences and Chemistry graduate students.
Prof. Pupo’s research interests center on both microbial natural products chemistry and their biological and ecological significance. Her laboratory is especially interested in all aspects of the discovery of novel natural products produced by symbiotic microorganisms, including endophytic and insect-associated fungi and actinobacteria. Most of her students and postdocs are engaged in the discovery of new antibiotics, antifungal, antiparasitic, and anticancer natural products. The microorganisms are also studied in biotransformation of natural products and drugs. Other approaches of particular interest include the utilization of mixed microbial cultures and chemical epigenetic modifiers to induce the expression of silent biosynthetic pathways. The lab is also interested in studying biosynthetic pathways by feeding experiments on both microorganisms and their host plants. The experimental procedures involve microbiological techniques for the isolation and cultivation of the microorganisms, chromatographic techniques for the isolation of the natural products, and NMR and MS experiments are extensively used for structure elucidation.